How Long Does It Take to Feel Better? (TMS, Spravato, Meds)

Ashley Keays • December 17, 2025

TMS, Spravato, and Medications Compared


When you’re struggling with depression, anxiety, or mood symptoms, one of the most common - and understandable - questions is:



“How long will it take before I start to feel better?”




The answer depends on the type of treatment, your personal history, and how your brain responds. Below, we break down realistic timelines for TMS therapy, Spravato (esketamine), and traditional antidepressant medications, so you know what to expect.


Why Timelines Vary So Much



Mental health treatment isn’t instant - and it isn’t one-size-fits-all. Factors that influence how quickly someone feels better include:


  • Severity and duration of symptoms
  • Prior treatment history
  • Medication sensitivity or side effects
  • Brain chemistry and neuroplasticity
  • Consistency of treatment


Improvement is often gradual, not sudden - and that’s normal.


TMS Therapy: Gradual, Lasting Improvement


Typical timeline:

🗓️ 2–4 weeks to notice changes


🗓️ 4–6 weeks for more significant improvement


🗓️ 6–8 weeks for full treatment response




What patients often notice first


  • Better sleep
  • Improved energy or motivation
  • Reduced mental “heaviness.”
  • Clearer thinking



TMS works by stimulating underactive brain regions and strengthening neural pathways over time. Because it’s retraining the brain, progress tends to be steady and durable, even after treatment ends.


Interested in learning more?


Schedule a consultation to see if TMS could be right for you.

Visit our contact page or call 253-900-1605 to speak with our team.

Request Appointment

Spravato (Ketamine): Faster Symptom Relief for Some


Typical timeline:


🗓️ 1–3 weeks for noticeable improvement


🗓️ Sometimes improvement after the first few sessions





Spravato works differently from traditional medications. It affects glutamate pathways, which may help lift depressive symptoms more quickly - especially for people with severe or treatment-resistant depression.



Important to know


  • Relief may feel faster, but it often requires ongoing maintenance
  • Effects can fluctuate between sessions
  • Best results usually come when combined with therapy or other care


Antidepressant Medications: Slower and Less Predictable


Typical timeline:


🗓️ 4–6 weeks for initial effects
🗓️ 6–8+ weeks for full response



Medications affect serotonin, norepinephrine, or dopamine - but the brain can take time to adjust. Some people feel better, others experience side effects before benefits, and some need multiple medication trials.



Common challenges include:



  • Delayed relief
  • Trial-and-error prescribing
  • Side effects that limit effectiveness



Timeline Comparison at a Glance

Treatment When Improvement Often Begins Notes
TMS Therapy 2–4 weeks Gradual, durable results
Spravato Days to weeks Faster relief, maintenance often needed
Medications 4–8+ weeks Variable response, trial-and-error

What If I Don’t Feel Better Right Away?


Not feeling immediate relief does not mean treatment isn’t working.

Progress often looks like:


  • Small improvements before big ones
  • Better days mixed with hard days
  • Changes others notice before you do


Your care team monitors progress closely and can adjust treatment when needed.


Which Option Is Right for You?


Choosing the right treatment depends on:


  • How long you’ve been struggling
  • How severe symptoms are
  • How you’ve responded to past treatments
  • Whether faster relief is needed
  • Your tolerance for medication side effects


That’s why a personalized evaluation matters.


Not Sure Where to Start? We Can Help

With so many treatment options, finding the right one can be overwhelming. Let’s make it easier. Answer a few quick questions, and we’ll help you discover what might work best for you

Take the Quiz →
Person writing on clipboard, interviewing another person, in a room with plants.
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