How Long Does It Take to Feel Better? (TMS, Spravato, Meds)

TMS, Spravato, and Medications Compared
When you’re struggling with depression, anxiety, or mood symptoms, one of the most common - and understandable - questions is:
“How long will it take before I start to feel better?”
The answer depends on the type of treatment, your personal history, and how your brain responds. Below, we break down realistic timelines for TMS therapy, Spravato (esketamine), and traditional antidepressant medications, so you know what to expect.
Why Timelines Vary So Much
Mental health treatment isn’t instant - and it isn’t one-size-fits-all. Factors that influence how quickly someone feels better include:
- Severity and duration of symptoms
- Prior treatment history
- Medication sensitivity or side effects
- Brain chemistry and neuroplasticity
- Consistency of treatment
Improvement is often gradual, not sudden - and that’s normal.
TMS Therapy: Gradual, Lasting Improvement
Typical timeline:
🗓️ 2–4 weeks to notice changes
🗓️ 4–6 weeks for more significant improvement
🗓️ 6–8 weeks for full treatment response
What patients often notice first
- Better sleep
- Improved energy or motivation
- Reduced mental “heaviness.”
- Clearer thinking
TMS works by stimulating underactive brain regions and strengthening neural pathways over time. Because it’s retraining the brain, progress tends to be steady and durable, even after treatment ends.

Interested in learning more?
Schedule a consultation to see if TMS could be right for you.
Visit our contact page or call 253-900-1605 to speak with our team.
Spravato (Ketamine): Faster Symptom Relief for Some
Typical timeline:
🗓️ 1–3 weeks for noticeable improvement
🗓️ Sometimes improvement after the first few sessions
Spravato works differently from traditional medications. It affects glutamate pathways, which may help lift depressive symptoms more quickly - especially for people with severe or treatment-resistant depression.
Important to know
- Relief may feel faster, but it often requires ongoing maintenance
- Effects can fluctuate between sessions
- Best results usually come when combined with therapy or other care
Antidepressant Medications: Slower and Less Predictable
Typical timeline:
🗓️ 4–6 weeks for initial effects
🗓️ 6–8+ weeks for full response
Medications affect serotonin, norepinephrine, or dopamine - but the brain can take time to adjust. Some people feel better, others experience side effects before benefits, and some need multiple medication trials.
Common challenges include:
- Delayed relief
- Trial-and-error prescribing
- Side effects that limit effectiveness
Timeline Comparison at a Glance
| Treatment | When Improvement Often Begins | Notes |
|---|---|---|
| TMS Therapy | 2–4 weeks | Gradual, durable results |
| Spravato | Days to weeks | Faster relief, maintenance often needed |
| Medications | 4–8+ weeks | Variable response, trial-and-error |
What If I Don’t Feel Better Right Away?
Not feeling immediate relief does not mean treatment isn’t working.
Progress often looks like:
- Small improvements before big ones
- Better days mixed with hard days
- Changes others notice before you do
Your care team monitors progress closely and can adjust treatment when needed.
Which Option Is Right for You?
Choosing the right treatment depends on:
- How long you’ve been struggling
- How severe symptoms are
- How you’ve responded to past treatments
- Whether faster relief is needed
- Your tolerance for medication side effects
That’s why a personalized evaluation matters.


















