Genetic Testing for Mental Health: Will It Help My Meds and TMS Plan?

Quick Introduction
Patients increasingly ask about pharmacogenetic testing (“PGx”) on intake forms - especially when medications haven’t helped or caused bad side effects. Genetic testing can provide useful clues about how your body processes certain psychiatric medications, and when used with thoughtful psychiatric care, it can speed up finding the right medication. But will it directly change your TMS plan? In most cases, PGx helps the medication-management piece of a broader treatment strategy - and that can help your overall outcomes when TMS is part of the plan.
What is pharmacogenetic testing (PGx)?
Pharmacogenetic testing analyzes genes that influence how your body metabolizes and responds to medications. The results commonly identify whether you metabolize a drug normally, too slowly, or too quickly - information that helps clinicians choose safer, better-tolerated medications or choose dosing adjustments. Clinics offering psychiatric care increasingly pair PGx reports with a psychiatrist review so results guide treatment decisions rather than dictate them.
How PGx helps medication management
When medication selection has been a process of trial-and-error, PGx can reduce guesswork by:
- Flagging likely ineffective or poorly tolerated medications based on metabolism genes,
- Helping clinicians choose alternatives that are more likely to be effective for your genetic profile, and
- Informing dose adjustments for certain drugs when metabolism differences are known.
At Creative Wellness, we integrate PGx with medication management - the psychiatrist reviews your test and personal history, then recommends a medication plan tailored to your biology and symptoms. This precision approach reduces time spent cycling through meds and can improve tolerability and effectiveness.
Does genetic testing change your TMS plan?
Short answer: not usually directly, but it matters indirectly.
- TMS is a brain-stimulation treatment whose target and protocol are chosen based on clinical presentation and mapping -PGx does not change the physics of stimulation. Creative Wellness performs mapping and sets TMS parameters clinically, independent of a PGx result.
- Where PGx helps is in medication coordination. Many patients receive TMS alongside medication management. If a patient’s meds are optimized using PGx, they may tolerate combined care better and experience clearer symptom changes while undergoing TMS. In short, PGx helps create a cleaner, safer medication backdrop during and after TMS.
- For certain side-effect concerns or medication interactions that could affect safety during treatment, PGx can guide safer choices that make TMS sessions smoother.
- If the TMS response is limited, your team may re-evaluate meds - PGx can be useful at that point to inform next medication steps.
Who should consider PGx testing?
Consider testing if you have any of the following:
- Tried multiple antidepressants or had significant side effects,
- Had mixed or partial responses to medications,
- Experienced intolerable side effects that forced you to stop meds, or
- Want to accelerate the path to a well-tolerated medication while planning combined care (TMS + meds).
Creative Wellness explicitly offers pharmacogenetic testing and consultation (for example, Tempus NeuroPsych is listed among testing options), and these services are offered as part of a medication-management pathway. Pricing and a consult option are available through the clinic.

Interested in learning more?
Schedule a consultation to see if TMS could be right for you.
Visit our contact page or call 253-900-1605 to speak with our team.
What the test can - and cannot - tell you
What it can do: identify metabolism differences (CYP enzymes), flag drug–gene interactions, and suggest which meds might be better or worse choices for you.
What it can’t do alone: guarantee a medication will work (clinical response depends on many factors) or predict your response to TMS itself. Results are one piece of the clinical puzzle and must be interpreted together with your history, symptoms, and clinician judgment.
How Creative Wellness integrates PGx with med management and TMS
- Intake & forms: Patients often request PGx on forms — the clinic flags candidates and discusses testing during evaluation. Creative Wellness uses test results to inform psychiatric medication planning.
- Psychiatry consult: The psychiatrist reviews PGx results alongside prior medication trials, symptoms, and safety considerations to recommend a personalized plan. This may include TMS + optimized meds, Spravato, or alternate strategies.
- Coordination with TMS: If you proceed with TMS, clinicians monitor how medication adjustments based on PGx interact with treatment and adjust as needed. If a medication-related safety concern arises, PGx informs choices to avoid interactions.
Practical next steps - what to ask your clinician
- “Do you recommend PGx testing for my situation?” Ask when your medication history includes multiple failed trials or significant side effects.
- “Which test do you use?” Creative Wellness lists Tempus NeuroPsych testing and a follow-up consultation option. Ask about cost and turnaround time.
- “How will you use my results with my TMS plan?” Expect a psychiatrist to explain how test findings shape medication choices and how medications will be coordinated with TMS sessions.
- “What about insurance or payment?” Some tests and psychiatry services may be out-of-pocket; confirm pricing and benefits during your consult.
Limitations, evidence & transparency
PGx is an evolving field with growing evidence that it improves medication tolerability and may shorten time to effective treatment for some patients - but it is not a magic bullet. Recommendations should be applied thoughtfully by a psychiatrist experienced in interpreting PGx results and integrating them into a broader treatment plan. Creative Wellness emphasizes coordinated care: genetic testing, medication management, and TMS under one clinical umbrella for the best outcomes.
Will PGx guarantee I won’t need TMS?
No. PGx helps choose and dose medications more safely and effectively, but some patients still benefit from TMS (or combined treatment) for treatment-resistant symptoms.
How long until I get results?
Turnaround varies by lab, but most neuropsych/PGx tests return results in days to a few weeks; your clinic will explain timing and next steps.
Is PGx expensive?
The prescribing psychiatrist or TMS medical director usually writes the clinical appeal letter - it’s the most persuasive documentation insurers see.


















